Publications
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Air-water interfacial and foaming properties of nanoparticles based on commercial and lab-scale isolated maize (Zea mays L.) zein KU Leuven
Maize zein based nanoparticles (ZNPs) can have applications as food dispersion stabilizers. It has not been documented to what extent the used zein isolation method and conditions thereof impact the structure and functionality of nanoparticles (NPs) based thereupon. Here, zein extracted from maize flour on lab scale (LS-zein) was compared with a commercial zein powder (CS-zein). On a dry matter basis, CS-zein contained 96.5% protein, while ...
Spermatogenesis in mouse testicular organoids with testis-specific architecture, improved germ cell survival and testosterone production Vrije Universiteit Brussel
This study presents a biphasic approach to overcome the limitations of current testicular organoid (TO) cultures, including histological heterogeneity, germ cell loss and absence of spermatogenesis. Agarose microwells were utilized to create TOs from prepubertal C57BL/6 J testicular cells. First emphasis was on improving germ cell survival during the initial 2-week reorganization phase by comparing α-MEM + 10% knockout serum replacement (KSR) ...
Relating the protein denaturation degree and solubility of soy protein isolates to the structure of high moisture extrudates KU Leuven Research Institute for Agriculture, Fisheries and Food
Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions. KU Leuven
Congenital myasthenic syndrome-22 (CMS22, OMIM 616224) is a rare genetic disorder caused by deleterious genetic variation in the prolyl endopeptidase-like (PREPL) gene. Previous reports have described patients with deletions and nonsense variants in PREPL, but nothing is known about the effect of missense variants in the pathology of CMS22. In this study, we have functionally characterized missense variants in PREPL from 3 patients with CMS22, ...
From Nanozymes to Multi-Purpose Nanomaterials: The Potential of Metal-Organic Frameworks for Proteomics Applications. KU Leuven
Metal-organic frameworks (MOFs) have the potential to revolutionize the biotechnological and medical landscapes due to their easily tunable crystalline porous structure. Herein, the study presents MOFs' potential impact on proteomics, unveiling the diverse roles MOFs can play to boost it. Although MOFs are excellent catalysts in other scientific disciplines, their role as catalysts in proteomics applications remains largely underexplored, ...
Data-driven probabilistic definition of the low energy conformational states of protein residues Vrije Universiteit Brussel KU Leuven
Protein dynamics and related conformational changes are essential for their function but difficult to characterise and interpret. Amino acids in a protein behave according to their local energy landscape, which is determined by their local structural context and environmental conditions. The lowest energy state for a given residue can correspond to sharply defined conformations, e.g. in a stable helix, or can cover a wide range of ...
The potential of alternative extraction technologies for the conventional extraction of pectin from plant-based side streams KU Leuven
To meet the growing demand for pectin, both the implementation of different pretreatments and alternative extraction technologies to improve the efficiency of the pectin extraction process, as well as the use of alternative pectin sources were investigated. Three industrially relevant plant-based side streams with an increasingly complex composition, being carrot pomace, broccoli stems and pumpkin pomace, were included in this research. The ...