Projects
Structural and functional characterization of the dual activity lipid phosphatase Synaptojanin 1 and its validation as a new drug target for intractable epilepsy Vrije Universiteit Brussel
5’ position of the inositol ring.
Upregulation ...
Yeast-based models to study the Alzheimer's disease associated protein Pin 1. KU Leuven
Life-course regulators of protein phosphatase-1 KU Leuven
Protein phosphatase-1 (PP1) catalyzes a substantial fraction of all protein Ser/Thr-dephosphorylation events and is essential for eukaryotic life. It forms highly selective and tightly regulated holoenzymes through association with a vast array of regulatory polypeptides. The large majority of PP1 interactors function as subcellular targeting subunits or substrate recruiters. A notable exception are the three first evolved and most conserved ...
Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1 KU Leuven
The synthesis of enzymes involves multiple, tightly regulated steps including transcription, translation, post-translational maturation, and the association of co-factors and regulatory subunits. Protein phosphatase-1 (PP1) is a very conserved and essential eukaryotic Ser/Thr phosphatase that functions as the catalytic subunit of at least 200 distinct holoenzymes. However, it is not understood how PP1 acquires its native conformation and ...
Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1 KU Leuven
NIPP1 (Nuclear Inhibitor of Protein Phosphatase 1) coördineert celgroei en DNA-foutenherstel via een inwerking op eiwitfosfatase-1, een enzym dat regulerende fosfaatgroepen verwijdert van talloze eiwitten. Cellen zonder NIPP1 groeien trager en zijn resistent tegen kankerverwekkende chemicaliën. Met dit onderzoeksproject beogen we, met behulp van nieuwe experimentele modellen, de onderliggende werkingsmechanismen te doorgronden. We zullen ...
Host cell phosphatases in the life cycle of DNA viruses KU Leuven
Integration of cellular signaling pathways in health and disease. KU Leuven
Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymes KU Leuven
Malignant mesothelioma is an aggressive cancer of the pleura and peritoneal cavities with limited treatment options. We have recently discovered that the pulse phosphorylation of protein kinase BUB1 functions as a timer for mitotic duration. In addition, this ‘BUB1 timer’ sensitizes cancer cells to anti-mitotic drugs and key components of the timer coordinate the (post)mitotic response to DNA-damage. Our objective is to explore whether the ...
Studying Dscam function in synaptic connectivity at single cell level. KU Leuven
Axonal branching is an essential mechanism in nervous system function, as it allows a single neuron to connect to multiple post-synaptic targets and thus increases the complexity and connectivity of neural networks. Collateral formation could be a therapeutic target to promote functional recovery in a wide range of nervous system diseases and injuries. However, the mechanisms allowing the formation and stabilization of specific ...