The role of prolyl hydroxylases of hypoxia inducible factor in bone development, homeostasis and pathology KU Leuven
Oxygen and nutrients are critical for the survival of cells. Beyond a certain size of a tissue, simple diffusion of oxygen becomes inadequate and cells will turn into a hypoxic state. An important aspect of cell survival is the ability to adapt to this stress situation. This adaptation encompasses on the one hand stimulation of angiogenesis to restore oxygen and nutrient supply, and on the other hand changes in cell metabolism to optimize energy ...