ENDOTHELIAL PKA ACTIVITY REGULATES ANGIOGENESIS BY LIMITING AUTOPHAGY THROUGH PHOSPHORYLATION OF ATG16L1 KU Leuven
The cAMP-dependent protein kinase A (PKA) regulates a plethora of cellular functions in health and disease. During angiogenesis, PKA activity in endothelial cells controls the transition from sprouting to vessel maturation and limits tip cell formation independently of Notch signaling. The molecular PKA targets mediating these effects remain unknown. We report a chemical genetics screen identifying endothelial-specific substrates of PKA in ...