Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1 KU Leuven
The synthesis of enzymes involves multiple, tightly regulated steps including transcription, translation, post-translational maturation, and the association of co-factors and regulatory subunits. Protein phosphatase-1 (PP1) is a very conserved and essential eukaryotic Ser/Thr phosphatase that functions as the catalytic subunit of at least 200 distinct holoenzymes. However, it is not understood how PP1 acquires its native conformation and ...