Projects
The influence of protease targeting drug leads on substrate processing characte rized in complex proteomes KU Leuven
Versatile chemical tools for profiling IgA1 protease activity in neisserial infections. University of Antwerp
Development of photo-activatable protease inhibitors and activity-based probes and their application in the study of dynamic proteolytic processes KU Leuven
Proteases are involved in many highly regulated biological processes, such as apoptosis, cell-cell communication and blood coagulation. Inhibitors and activity-based probes (ABPs) have been successfully utilized as chemical tools to study these enzymes. However, when studying fast and dynamic processes, local and temporal acivation of these reagents is desirable. Such reagents can first of all be used for basic study of these processes, but ...
Validation of small molecule inhibitors of MALT1 protease for the treatment of auto-immune disorders and NF-κB-addicted lymphomas. KU Leuven
Current scientific literature highlights MALT1 protease activity as an important therapeutic target for treating NF-κB-mediated diseases such as autoimmune disorders and lymphoma. In collaboration with CD3 we have developed and patented three classes of MALT1 small molecule inhibitors that affect MALT1 substrate cleavage in cells and that reduce processes regulated by MALT1 protease activity such as IL2 production by and proliferation of ...