Projects
"Functional characterization of mammalian LonP2, a peroxisomal AAA protease" KU Leuven
Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. University of Antwerp
Spatiotemporal control of protease activity by photoactivatable inhibitors KU Leuven
Proteases are involved in the regulation of many biological
processeses in the body. Dysregulation of protease activity plays a
role in many diseases, including cancer, Alzheimer’s disease and
hypertension. Therefore, proteases are considered as interesting
drug targets. It is clear that we need both fundamental understanding
of protease function and efforts to develop protease targeting drugs.
Some protease ...
The development of novel quenched fluorescent activity-based probes and their application in the visualization of serine protease activity in living cells by microscopy and flow cytometry KU Leuven
Proteases are enzymes that cut proteins. Although some play a role in food digestion, most are involved in the regulation of specific biological processeses in the body. Aberrant protease activity contributes to the development of diseases, and proteases can therefore be used as drug targets and diagnostic markers. For example, some tumor types display an increased protease activity. If we were able to localize a particular protease and show ...
The influence of protease targeting drug leads on substrate processing characte rized in complex proteomes KU Leuven
Study of the protease inhibitor induced adaptation in two pest insects. KU Leuven
Versatile chemical tools for profiling IgA1 protease activity in neisserial infections. University of Antwerp
Protease dependent regulation of IL-33 activity in allergic airway inflammation Ghent University
The prevalence of allergies has risen over the last decades. It is evident that the host immune
system and airway mucosal response determine the development of sensitivity or tolerance to
inhaled allergens.
The status of airway mucosa could predetermine the development of severe airway diseases,
including severe asthma and chronic rhinosinusitis with nasal polyps. Current therapies are often
not helpful in ...
Lighting and decoding the world of serine protease KU Leuven
Serine proteases are the largest catalytic family of proteases in the human genome. They have been implied in various diseases including cancer, diabetes, atherosclerosis and neurodegenerative diseases. The detectcion of abberrant serine protease activity can therefore shed light on different physiological and pathological processes. In this plan, I will design fluorescently quenched activity- based probes (qABPs) for two families of serine ...