Laboratory of Chemical Biology KU Leuven
The Laboratory of Chemical Biology develops and applies small molecule tools that covalently modify proteins according to a certain trait. We particularly focus on molecules named activity-based probes. These react with active enzymes within a whole proteome and enable a read-out by SDS-PAGE, mass spectrometry, fluorescence spectroscopy or microscopy. Besides probe development, we focus on several protease families including the intramembrane ...