Publications
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Osteopontin alters the functional profile of porcine microglia **in vitro** University of Antwerp
OPN (osteopontin) is a secreted glycoprotein predominantly expressed in bone matrix and kidney tissue. More recently, a neuroprotective role has been attributed to this cytokine since it can be up-regulated by microglia in neurodegeneration and inflammation. We demonstrate the expression of OPN within primary cultured microglia. Microglia incubated in vitro with different concentrations (0.1 fM1 nM) of recombinant OPN showed increased ...
Differential gene expression profile of porcine livers subjected to warm ischemia alone KU Leuven
BACKGROUND: Livers exposed to warm ischemia (WI) are increasingly used for transplantation. The molecular mechanisms activated by WI alone (prior to procurement and transplantation) are not understood. To elucidate the pathways involved, we used microarrays to investigate the gene expression in porcine livers exposed to WI. METHODS: Porcine livers (n = 6 group) were randomly subjected to WI periods of 15, 30 or 45 minutes. mRNA was extracted and ...
Ensemble RBS: Probing the compositional profile of 3D microscale structures Interuniversity Microelectronics Centre KU Leuven
Rutherford backscattering spectrometry (RBS) is an analytical method able to provide quantitatively elemental information with high accuracy in the near surface region of samples. However, the technique conventionally lacks the required (sub)micron spatial resolution for many semiconductor applications. Firstly, the ion beam current of a highly focused beam is very small, limiting the analytical sensitivity of the measurement. Secondly, the ...
Complete genome analyses of the first porcine rotavirus group H identified from a South African pig does not provide evidence for recent interspecies transmission events KU Leuven
Rotaviruses (RVs) are classified into eight species/groups (RVA-RVH) according to the migration patterns of their 11 genome segments, as well as by serological and molecular properties of Viral Protein 6 (VP6). In 1997 a new unclassified RV was reported infecting adults in Bangladesh and China. This virus was initially named novel adult diarrhoea rotavirus (ADRV-N), but later renamed as RVH. Since then, RVH has been detected in humans only very ...
The Fcγ receptor expression profile on porcine dendritic cells depends on the nature of the stimulus KU Leuven Ghent University
Nowadays, vaccine research focuses on the development and implementation of subunit vaccines into existing or future vaccination platforms. However, recombinant proteins are often poor immunogens, necessitating adjuvants to activate and direct the immune response. Alternatively, the immunogenicity of antigens can be enhanced by targeting antigens to Fcγ receptors on antigen-presenting cells and as dendritic cells (DCs) are the most potent ...
The Fcγ receptor expression profile on porcine dendritic cells depends on the nature of the stimulus KU Leuven
Nowadays, vaccine research focuses on the development and implementation of subunit vaccines into existing or future vaccination platforms. However, recombinant proteins are often poor immunogens, necessitating adjuvants to activate and direct the immune response. Alternatively, the immunogenicity of antigens can be enhanced by targeting antigens to Fcγ receptors on antigen-presenting cells and as dendritic cells (DCs) are the most potent ...