Publications
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ARIA 2016 executive summary: Integrated care pathways for predictive, preventive and personalized medicine across the life cycle KU Leuven Ghent University
La médecine préventive Institute of Tropical Medicine
La médecine préventive Institute of Tropical Medicine
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. KU Leuven Flanders Institute for Biotechnology
Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal, i.e. slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be the optimal therapeutic modality for AD prevention, as we will discuss in the context of the earlier small molecules described as "γ-secretase modulators" (GSM). We review here the structure, function, and pathobiology of γ-secretases, with a focus on how ...
Causes and prevention of long-term disability due to low back pain. An inquiry from the perspective of insurance medicine. KU Leuven
Background In western societies, low back pain (LBP) is one of the leading disorders resulting in long-term disability. In Belgium, disability is compensated through the Belgian Social security system where medical advisers of sickness funds play a key role in the disability evaluation of claimants. In daily practice, they are often confronted with claimants suffering from LBP and LBP surgery. Over the years, there has been a change of focus ...