Projects
Do the EU and relevant national legal frameworks provide for a fair allocation of data control and responsibility in the context of precision medicine? A case study of clinical trials KU Leuven
Clinical research relies on patient participation and the use and (re-)use of sensitive personal data. Moreover, several types of research are heavily dependent on exchange of data between countries (e.g., precision medicine trials), and all health research would benefit from greater, meaningful cross-border collaborations, as shown during the COVID-19 crisis. However, the current legal system for the conduct of cross-border research in the ...
Towards PRecision MEdicine for Osteoarthritis: added value of cognitive behavioral therapy for insomnia (the PREMEO trial). KU Leuven
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation. The first-line KOA management is nonsurgical care, with education and exercise therapy as key elements. Nevertheless, treatment effects of exercise therapy and behavioral pain management on improvements in pain, function and quality of life are small to moderate at best. ...
Paving the way to precision medicine in childhood-onset diseases: A lifespan perspective on accelerated aging using the epigenetic clock Ghent University
Many childhood-onset diseases used to be lethal. Improved life expectancy yield that most patients can survive into adulthood, to date. However, survivors of childhood-onset diseases often develop morbidities that suggest accelerated aging. Congenital heart disease is a typical example of a childhood-onset disease. It is the most common birth defect, comprising a spectrum of mild, moderate and complex heart defects. Several age-related ...
PREMEO Trial : Towards PREcision MEdicine for Osteoarthritis: added value of cognitive behavioural therapy for insomnia Vrije Universiteit Brussel
• Secondary objectives of the study are to examine if CBTi-UC is more effective ...
Building a Precision Medicine Pipeline for Antibody-Mediated and Antibody-Independent Phenotypes of Microvascular Rejection After Kidney Transplantation KU Leuven
Immunosuppressive regimens for prevention and treatment of rejection have been established over the past 50 years, but focused on T-cell activation and proliferation. Long-term outcome after renal transplantation is impaired, which is attributed in large part to rejection caused by donor-specific HLA antibodies. Although it is becoming clear that antibody-mediated rejection is the prime cause of late renal allograft failure, preventative ...
Paving the way to precision medicine in childhood-onset diseases: A lifespan perspective on accelerated aging using the epigenetic clock KU Leuven
Many childhood-onset diseases used to be lethal. Improved life
expectancy yield that most patients can survive into adulthood, to
date. However, survivors of childhood-onset diseases often develop
morbidities that suggest accelerated aging. Congenital heart disease
is a typical example of a childhood-onset disease. It is the most
common birth defect, comprising a spectrum of mild, moderate and
complex heart ...
Transcriptomics in CKD-MBD; On the road to precision medicine KU Leuven
Brief background Chronic kidney disease (CKD) is a common health problem affecting 10-15% of the population. Patients with CKD suffer multiple metabolic complications, among them mineral and bone disorders (MBD). CKD-MBD results in excessive morbidity and mortality due to fractures and cardiovascular disease. Progress within the field of renal bone disease (commonly referred to as renal osteodystrophy [ROD]) is hampered by a lack of validated ...
SOX11 as mediator of the adrenergic cell state in neuroblastoma: towards cell precision medicine Ghent University
Neuroblastoma (NB) is a pediatric tumor arising from the peripheral nervous system with still poor survival for high-risk patients despite intensive therapy. Recent studies discovered two different phenotypic subpopulations in NB tumors, i.e. so-called adrenergic (ADRN) and neural-crest cell/mesenchymal like (NCC/MES) cells. The latter cell type is more chemo-tolerant and enriched in post-therapy and relapse tumors. We recently identified ...
Rectal sampling and ambient ionization based metabolomics for point-of-care precision medicine in children. Ghent University
While recent advent of hyphenated high-resolution mass spectrometry empowered the new analytical reality of holistic
metabolite fingerprinting, there are at present no tools available for point-of-care minimally invasive sampling of the gut
metabolome. The gut metabolome harbors a rich source of data that allows complex interactions between the diet, gut
microbes and host to be studied. Numerous chronic conditions ...