Integrative interactome and protein modification analysis of HNF4α in sepsis Ghent University
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Recent insights have endorsed the importance of energy metabolism in the pathophysiology, governed by the liver. Previous research by our group links the downregulation of certain metabolic genes in sepsis to a loss of function and reduced DNA-binding activity of HNF4α, a key transcription factor. The transcriptional activity of nuclear ...