Post-translational modification of GRP78 and its role in human Type 1 diabetes KU Leuven
Type 1 diabetes (T1D) is a childhood autoimmune disease in which insulin producing beta cells are targeted and destroyed. This project builds on recent observations indicating that modification of self-proteins is a possible mechanism for acceleration of autoimmunity and progression to T1D. Our goal is to elucidate the mechanisms by which self-proteins are modified due to stress, how such modifications increase immune recognition, and whether ...