Genetic variants affecting cGMP signal transduction in early LV dysfunction and transition to heart failure: a prospective population study and proof-of-concept intervention stufy. KU Leuven
Despite significant advances in our understanding and treatment of heart failure, this syndrome remains a major public health problem and once established, it is a major cause of mortality and morbidity in Western and industrialized societies. In this project we want to focus on the role of the nitric oxide – cyclic guanosine monophosphate (NO-cGMP) signaling pathway, and more particular the genetic variants of different components in this ...