Projects
Development of a human induced pluripotent stem cell-derived 3D liver NAFLD culture model. Vrije Universiteit Brussel
A novel epigenetic modification in pluripotent stem cells. KU Leuven
In mammalian cells, a major epigenetic modification of DNA is methylation of cytosine. DNA methylation is critical during mammalian development, generally represses transcription when present at gene promoters and regulates cell lineage-specific gene expression programs. Conversely, during cellular reprogramming, efficient erasure of DNA methylation is essential for reactivation of previously silenced genes and for attaining pluripotency. The ...
Screening platform for therapies for peripheral neuropathies (SCREEN4PN) in induced pluripotent stem cell derived 2D and 3D models (extension of development phase 2). University of Antwerp
Development and validation of human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) assays to predict functional and structural cardiac liabilities. University of Antwerp
Investigating the therapeutic potential of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS) using human induced pluripotent stem cells (iPSCs). KU Leuven
The aim of this project is to investigate the role of HDAC6 in ALS and to find out which effect the inhibition of HDAC6 has on different ALS-related processes. More specifically, we will investigate the role of HDAC6 in axonal transport, in axonal outgrowth and the formation of neuromuscular junctions, in the cellular redox state and the protection against DNA damage and in the protein quality control systems. Obtaining better insights into ...
Screening platform for therapies for peripheral neuropathies (SCREEN4PN) in induced pluripotent stem cell derived 2D and 3D models (development phase 2). University of Antwerp
Liver and brain organoids to model human pluripotent stem cell tumorigenesis Vrije Universiteit Brussel
stem cell-derived (hPSC) cells is their potential for tumour formation.
Up to now, research has focused on the possibility that poorly
differentiated or progenitor cells initiate tumour formation upon
transplantation. Conversely, hPSC are prone to acquiring genetic
abnormalities that are very similar to those identified in cancers and
...
Pathomechanistic study of RCBTB1-associated inherited retinal disease using Xenopus tropicalis and patient-derived induced pluripotent stem cells Ghent University
We identified RCBTB1 as novel disease gene for inherited retinal disease. Proof-of-concept from a
Xenopus tropicalis rcbtb1 knockout and human deep phenotyping led to the hypothesis that
RCBTB1-disease affects RPE-biology. Key objectives are to understand RPE-disease progression
at the organismal level in the Xenopus tropicalis rcbtb1 knockout and in a patient-derived RPE
cellular model, and to characterize the ...