Improved disease modelling and genetics for inherited platelet disorders KU Leuven
Inherited platelet disorders (IPD) are highly heterogeneous with genetic defects in 63 genes and characterized by a high susceptibility to bleeding and often associated with syndromic features. Many genes have been discovered by whole exome/genome sequencing (WES/WGS) but their exact role in platelet formation and function remains unknown due to the lack of animal or efficient cell-based models. Today, high throughput-sequencing multi-gene ...