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Daratumumab for relapsed or refractory AL amyloidosis with high plasma cell burden Vrije Universiteit Brussel

Sofie Brouwers

Daratumumab, an anti-CD38 antibody, is effective in AL amyloidosis with low tumor burden. Data of daratumumab treatment in patients with AL amyloidosis but high tumor burden (≥10% bone marrow plasma cells) are limited. We report retrospective data of 10 consecutive patients with high tumor burden treated with daratumumab for relapsed/refractory AL amyloidosis. The median age at diagnosis was 62.3 years; all patients had cardiac involvement, ...

Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor Vrije Universiteit Brussel

Raf Van Campenhout, Serge Muyldermans, Mathieu Vinken, Nick Devoogdt, Timo De Groof
Cell plasma membrane proteins are considered as gatekeepers of the cell and play a major role in regulating various processes. Transport proteins constitute a subclass of cell plasma membrane proteins enabling the exchange of molecules and ions between the extracellular environment and the cytosol. A plethora of human pathologies are associated with the altered expression or dysfunction of cell plasma membrane transport proteins, making them ...

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group Vrije Universiteit Brussel

C. Fernández De Larrea, Robert Kyle, Brian Durie, Heinz Ludwig, S Usmani, Dh Vesole, Jésus F. San Miguel, Orthan Sezer, Pieter Sonneveld, Sk Kumar, et al.
Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. Primary PCL is a distinct clinic-pathological entity with different cytogenetic and molecular findings. The clinical course is aggressive with short remissions and survival duration. The ...

Plasma cells in primary melanoma. Prognostic significance and possible role of IgA KU Leuven

Francesca Bosisio, Jasper Wouters, Marguerite Stas, Joost van den Oord
Melanoma is not only one of the most immunogenic cancers but also one of the most effective cancers at subverting host immunity. The role of T lymphocytes in tumor immunity has been extensively studied in melanoma, whereas less is known about the importance of B lymphocytes. The effects of plasma cells (PCs), in particular, are still obscure. The aim of this study was to characterize pathological features and clinical outcome of primary ...

Auranofin and cold atmospheric plasma synergize to trigger distinct cell death mechanisms and immunogenic responses in glioblastoma University of Antwerp

Jinthe Van Loenhout, Delphine Quatannens, Jorrit De Waele, Céline Merlin, Hilde Lambrechts, Ho Wa Lau, Christophe Hermans, Abraham Lin, Marc Peeters, Annemie Bogaerts, et al.
Targeting the redox balance of malignant cells via the delivery of high oxidative stress unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a novel reactive oxygen species (ROS)-inducing combination treatment strategy, by increasing exogenous ROS via cold atmospheric plasma and inhibiting the endogenous protective antioxidant system via auranofin (AF), a thioredoxin reductase 1 (TrxR) inhibitor. The sequential ...

Plasma GAD65, marker for early beta cell loss following intraportal islet cell transplantation in diabetic patients Vrije Universiteit Brussel KU Leuven

Rui Mao, Christiane S Hampe, Åke Lernmark

CONTEXT AND OBJECTIVE: Intraportal islet transplantation can restore insulin production in type 1 diabetes patients but its effect is subject to several interfering processes. To assess the influence of beta-cell loss before and during engraftment we search for a real-time marker of beta-cell destruction. Previous studies showed that GAD65 is discharged by chemically damaged rat beta cells. We therefore examined the utility of the GAD65 assay ...

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model KU Leuven

Lies De Groef, Lieve Moons
PURPOSE: To investigate the effect of plasma kallikrein (PKal)-inhibition by THR-149 on preventing key pathologies associated with diabetic macular edema (DME) in a rat model. METHODS: Following streptozotocin-induced diabetes, THR-149 or its vehicle was administered in the rat via either a single intravitreal injection or three consecutive intravitreal injections (with a 1-week interval; both, 12.5 µg/eye). At 4 weeks post-diabetes, the effect ...

External quality assessment schemes for biomarker testing in oncology comparison of performance between formalin-fixed, paraffin-embedded-tissue and cell-free tumor DNA in plasma University of Antwerp KU Leuven

Kaat Van Casteren, Cleo Keppens, Ed Schuuring, Zandra C. Deans, Nicola Normanno, Simon J. Patton, Elisabeth M. C. Dequeker
Liquid biopsies have emerged as a useful addition to tissue biopsies in molecular pathology. Literature has shown lower laboratory performances when a new method of variant analysis is introduced. This study evaluated the differences in variant analysis between tissue and plasma samples after the introduction of liquid biopsy in molecular analysis. Data from a pilot external quality assessment scheme for the detection of molecular variants in ...

A Comparison of Cell-Free DNA Isolation Kits Isolation and Quantification of Cell-Free DNA in Plasma University of Antwerp

Laure Sorber, Christian Rolfo, Patrick Pauwels
The analysis of cell-free DNA (cfDNA) as a sensitive biomarker for cancer diagnosis and monitoring has resulted in a need for efficient and standardized cfDNA isolation. In this study, we compared the isolation efficiency of the QIAamp circulating nucleic acid kit (QIA) with four other cfDNA isolation kits: the PME free-circulating DNA Extraction Kit (PME), the Maxwell RSC ccfDNA Plasma Kit (RSC), the EpiQuick Circulating Cell-Free DNA Isolation ...

Reduction of human glioblastoma spheroids using cold atmospheric plasma University of Antwerp

Angela Privat Maldonado, Yury Gorbanev, Evelien Smits, Annemie Bogaerts
Cold atmospheric plasma (CAP) is a promising technology against multiple types of cancer. However, the current findings on the effect of CAP on two-dimensional glioblastoma cultures do not consider the role of the tumour microenvironment. The aim of this study was to determine the ability of CAP to reduce and control glioblastoma spheroid tumours in vitro. Three-dimensional glioblastoma spheroid tumours (U87-Red, U251-Red) were consecutively ...