Development of a coupled source and receiver model for vibrations due to urban railway traffic. KU Leuven
This dissertation addresses the development and ...
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with pleiotropic ocular, skeletal and cardiovascular manifestations. Morbidity and mortality are mostly determined by aortic root aneurysm, dissection and rupture. Although mutations in FBN1, coding for fibrillin-1, are the sole genetic MFS cause, there is a poor correlation between the MFS phenotype and the nature or location of the FBN1 variant. Wide intra- and ...
Amines are important nitrogen-containing components with a wide range of applications, such as the synthesis of polyamides or Nylon. Today, amines are mainly produced from fossil sources. An interesting alternative method is the valorisation of biomass and residual flows for the production of such components. Therefore, in this PhD research, strategies were developed for the direct conversion of carboxylic acids and carboxamides to (primary) ...
Alzheimer’s disease (AD) is characterized by amyloid β (Aβ) plaques and tangles. These hallmarks appear relatively late in disease stirring the debate whether they are a consequence of earlier pathogenic processes. Herein intracellular Aβ accumulation precede their formation, and correlates better with synaptic dysfunction and cognitive decline. Our recent data suggest that the composition of Aβ yielding γ-secretase complexes plays a role in ...