I-PREDICT: Innovative Physiology-based pharmacokinetic model to pREdict Drug exposure In neonates undergoing Cooling Therapy KU Leuven
Drug disposition in neonates depends on maturational and non-maturational covariates. We hypothesize that cooling, a standard therapy for asphyxiated neonates with hypoxic-ischemic encephalopathy, is such a non-maturational covariate. The main goal of the project is to develop an innovative physiology-based pharmacokinetic (PBPK) framework to describe and predict the impact of cooling on drug disposition in asphyxiated neonates. PBPK models ...