Unraveling the role of RIPK1 phosphorylation in TNF-mediated cell death and inflammation Ghent University
Tumor necrosis factor (TNF) is a master pro-inflammatory cytokine whose pathogenic role in
inflammatory disorders has long been attributed to the induction of pro-inflammatory mediators.
Very recent in vivo studies demonstrated that TNF also causes inflammation by inducing RIPK1
kinase-dependent cell death. Consequently, RIPK1 is emerging as an attractive therapeutic target
in the treatment of TNF-driven inflammatory ...