Projects
Phosphodiesterase 4B and 4D inhibition: A sequential approach to unlock spinal cord injury repair Hasselt University
Evaluation of the role of phosphodiesterase 7 and 10 in obsessivecompulsive disorders by positron emission tomography. University of Antwerp
Targeting phosphodiesterase 4D (PDE4D) isoforms, a novel approach to boost repair in multiple sclerosis Hasselt University
translational study of the modulation of fosfodiesterase type 10A expression by dopaminergic neurotransmission using molecular imaging KU Leuven
Phosphodiesterases are enzymes that break down important signaling molecules (cGMP and cAMP). The phosphodiesterase subtype 10A (PDE10A) is present only in a specific substructure in the brain (“striatum”) which is related to movement disorders such as Huntington’s (HD) and Parkinson’s disease (PD). PDE10A is also a new drug target for treatment of schizophrenia. We have developed a radioactive substance (“radiotracer”) that binds to PDE10A. ...
Supporting the oligodendrocyte-neuron coupling: pulling back to curtain on downstream PDE4D signalling Hasselt University
Out-of-control microglia cause cognitive deficits through excessive synaptic elimination in Alzheimer's Disease Hasselt University
Targeting microglia-mediated excessive synaptic elimination in Alzheimer's Disease Hasselt University
Out-of-control microglia cause cognitive deficits through excessive synaptic elimination in Alzheimer's Disease Hasselt University
Role of PDE10A in Alcohol Addiction: combining multimodal neuroimaging techniques and advanced learning strategies to predict relapse propensity KU Leuven
Alcohol addiction is the most common complex psychiatric disorders affecting society. However, the exact signaling pathways and mechanisms underlying the development of alcohol addiction and the relapse propensity are still unclear. Phosphodiesterase 10A (PDE10A) is a dual substrate enzyme highly enriched in striatal medium spiny neurons, where it regulates intracellular signaling processes including dopaminergic transmission. PDE10A is ...