Development and validation of a juvenile porcine model to study antibiotic tissue pharmacokinetics in pediatric sepsis. Ghent University
Performing pediatric drug research is extremely challenging. The development of animal models have been encouraged in guidance documents issued by the regulatory agencies. Pigs display a high degree of anatomical and physiological similarity to humans and are propagated as innovative juvenile animal model for reliable prediction of pediatric pharmacokinetic (PK) behavior. Previous research on antibiotic dose optimization in children is based ...