Gas chromatography (GC) is a well-established separation technique based on the selective interaction of the analytes in the gas phase (and moving by the mobile phase) with the stationary phase. As analytes should be easily volatilised, its use is somehow limited, often requiring long pre-treatments. In this work, the use of less conventional headspace (HS) modes such as multiple headspace (MHE), total volatilization (TVT) and full ...
Modelling of the drying process of porous granules in pharmaceutical continuous operation: a mechanistic approach Ghent University
Mechanistic models of pharmaceutical processes are required to predict and control the continuous production of tablets based on real-time measurements and adjustment of significant process variables. The development of these models will adopt a step-wise approach. In this project the focus will be the drying process of wer granules in a fluidized bed dryer.
Implementation of Process Analytical Technology (PAT) systems in Pharmaceutical Production Processes Ghent University
This project aims to develop a general strategy to implement and validate PAT systems in pharmaceutical production processes, allowing real-time release of the end product. Herewith, major attention is paid to the necessary use of complimentary PAT tools: in-line and real-time process analyzers (especially spectroscopic techniques), chemometrics, process control tools and knowledge management tools.
The development of a flow sheet model for a full continuous pharmaceutical from-powder-to-tablet manufacturing line to gather process knowledge and the development of control strategies Ghent University
Mechanistic models of pharmaceutical processes are required to predict and control the continuous production of tablets based on real-time measurements and adjustment of significant process variables. The development of these models will adopt a step-wise approach. In this project the focus will be the modelling of a full continuous from-powder-to-tablet manufacturing line
Design space estimation and validation of an innovative continuous pharmaceutical production process Ghent University
The project focusses on the optimization and validation of a continuous granulation process. Based on the critical process parameters, the aim is to translate data collected from process analyzers into a space of process parameters, displayiing the probability to meet the product targeted performance. This allows predicting the process parameters leading to the expected product specifications with a high probability.
The pharmaceutical industry has been traditionally a very innovative industry when discovering new drugs. When it comes to manufacturing platforms, the industry still relies on some very standard set of unit operations in manufacturing platform. During manufacturing, pharmaceutical raw materials (i.e., active drug compounds and excipients) are processed by several consecutive process steps or process phases, leading to a U+FB01nal product ...
Mechanistic & Empirical Modeling for the PHarmaceutical InduStry Ghent University
Together with a company, a strategic partnership has been set up for the joint development and marketing of continuous freeze-drying technology. Within this partnership, the pharmaceutical and process analytical knowledge of UGent is combined with the company's engineering and market knowledge. The objective of this project is to develop a 'GMP-ready' industrial prototype. Starting from this prototype, valorization activities will be deployed ...
Implementation of a Process Analytical Technology (PAT) system into an innovative continuous pharmaceutical production proces Ghent University
This project aims at developing and validating a process analytical technology (PAT) system for a new continuous pharmaceutical from-powder-to-tablet process (Consigma). Process analyzers supplying multivariate information will be applied to monitor in-line the critical and product quality aspects. Process control methods will be developed allowing continuous steering of the process, hence guiding the process towards its desired end ...