Projects
Integrated computer modelling of cardiorespiratory fitness for personalised risk profiling and heart failure prevention KU Leuven
Clinical exercise tests could improve the personalized risk profiling and management of cardiovascular disease. Yet, current practice only considers a limited selection of cardiopulmonary exercise indexes in isolation. To utilize the full value of clinical exercise testing data, we will apply advanced machine learning (ML) approaches on big data that has been collected/will be collected in patients at UZ Leuven (n=1800) and within the general ...
integrating risk profiling in decision support tools Ghent University
The research project objective is to quantify the risk attitude of decision makers using experimental economics. This risk profile is then validated with the observed choice of decistion makers. A validated risk profile can finally be used in decision support tools that endogenously take risk, uncertainty and variation into account including the personal risk attitude of the decision maker.
Integrative personalized computer modeling for better cardiovascular health assessment KU Leuven
The cardiovascular (CV) area has tremendous potential for personalized medicine and is currently under fast development. Precise description of CV health and risk assessment are essential for optimal prevention and treatment strategies, but requires complex integration of many factors. Development of computer population-based models will ultimately support precision medicine. Therefore, the specific aims of this project are: (1) Applying ...
Advancing Liquid Biopsies for Monitoring and Personalized Treatment of Children with Neuroblastoma Ghent University
The embryonal tumor, neuroblastoma, accounts for 11% of all cancer-related deaths in children. Its heterogeneous tumor biology creates clinical variability spanning spontaneous regression to rapid metastasizing progression. Long-term survival of high-risk disease remains poor, with <40% overall survival after first-line treatment and <10% after relapse, despite considerable international efforts to improve treatment over the last ...
Multiple sclerosis: from genetic and immunological profile to personalized medicine. KU Leuven
Over the past few years, researchers and clinicians in MS have made substantial progress in understanding and treating multiple sclerosis (MS). First, more than 110 genetic risk factors for MS have been identified. These risk factors point to a crucial role of the immune system and indicate new targets for treatments. Secondly, we start to understand some of the important differences between patients that are remarkable in MS. For others, ...
Comparing the knee joint loading profile of early post-traumatic And non-traumatic knee osteoarthritis: towards prevention of Progression with more personalized rehabilitation. KU Leuven
Knee osteoarthritis (OA) is a leading cause of disability and a source of high societal burden. Developing individualized strategies to prevent progression from the early stage on, is thus of utmost importance. One of the main risk factors for progression is believed to be repetitive (pathological) loading on the joint during everyday activities. However, the underlying mechanistic events and distinct loading profiles in early post-traumatic ...