Projects
‘Preloading’ amongst students: how much, what and why? KU Leuven
Drinking at university is a well-known phenomenon that is problematic not only because it might be excessive, but also because it happens at a period in time in which a student’s choices and successes might have a lasting effect on his entire life. In this respect, the practice of preloading (consuming alcohol before going to an event or participating in an activity where extra alcohol is consumed or not) is observed in many countries. ...
Direct integrative single-cell sequencing of Acute Lymphoblastic Leukemia patients KU Leuven
Leukemia is a complex disease caused by the accumulation of oncogenic lesions in developing lymphoid cells. This hematologic malignancy shows extensive genetic intra-tumoral heterogeneity. However, we still do not fully understand how it develops, the exact type of cells that compose it and the sensitivity of the different cells to the treatment. In order to dissect heterogeneity, it is essential to perform studies with single-cell ...
Pragmatic language skills in children with 22q11.2 deletion syndrome and Williams syndrome KU Leuven
Pragmatics, as a part of linguistic competence, can be defined as the ability of a person to use language across different social contexts. In the last two decades the study of the development and use of pragmatic language skills in children with intellectual disabilities has known a remarkable growth. Pragmatic abilities of this population are an interesting study area because of their connection to cognition, social skills, functional ...
Individualized Paediatric Cure: Cloud-based virtual-patient models for precision paediatric oncology Ghent University
Effective personalized medicine for paediatric cancers must address a multitude of challenges, including domainspecific challenges. To overcome these challenges, we propose a comprehensive computational effort to combine knowledge-base, machine-learning, and mechanistic models to predict optimal standard and experimental therapies for each child. Our approach is based on virtual patient models–in-silico avatars whose analysis can inform ...
Breath analysis as a non-invasive biomarker for the early detection of preclinical type 1 diabetes. University of Antwerp
Postpartum breast cancer diagnosed during the post-weaning period: a distinct entity with unique clinicopathological, molecular and immunological features? KU Leuven
Background Postpartum breast cancer (PP-BC) represents an under-recognized, yet high-risk subset of breast cancer diagnosed in young women. Breast cancers that occur 1 to 2 years postpartum are characterized with a 2-fold increased risk for metastasis and higher death rates in comparison to breast cancers diagnosed in age-matched women outside but also during pregnancy. The poorer prognosis and increased risk for metastasis ...