Projects
Cell-free nucleic acid profiling in diffuse large B-cell lymphoma: a molecular guidance to precision medicine Ghent University
Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin’s lymphomas. DLBCL is an aggressive malignancy that displays major heterogeneity in terms of morphology, genetics and biological behavior. While complete remission is obtained in 70% of cases, patients with refractory or relapsed disease have a poor prognosis. Current classifications fail to identify high-risk subgroups and improve their outcomes. In ...
Understanding heterogeneity in preschoolers at risk for struggling with mathematics learning: profile analyses and dynamic assessments KU Leuven
Understanding heterogeneity in preschoolers at risk for mathematical learning difficulties via latent profile analysis KU Leuven
It has been repeatedly observed that children vary substantially in their levels of mathematical knowledge prior to school entry with some children already showing difficulties in their mathematical skills. These difficulties have been labelled to be highly heterogeneous, although the existing body of evidence has not investigated this heterogeneity in early mathematical skills in preschool via a person-centered approach in struggling ...
Towards prediction and therapeutic targets of Alzheimer's disease through directed analysis of genetic risk loci. University of Antwerp
ProFiLE:Standardized multi-parameter flow cytometry for early diagnosis, risk assessment and optimized treatment in primary immunodeficiency KU Leuven
Primary Immune Deficiency diseases (PIDs) comprise a heterogeneous group of life-threatening genetic disorders of the innate and adaptive immune system. To date, more than 400 different PID subtypes with more than 300 PID causing genes have been unraveled. However, there is still a lot of underdiagnosis due to the clinical heterogeneity in disease presentation even among patients with the same genetic pathogenic variant. Further complicating ...
Identification and specification of the risk for 'hamstring strain injury " for the football player Ghent University
The research embedded within this doctoral thesis focused on the intrinsic hamstring injury risk profile in male football players. In spite of the substantial amount of effort that is being invested in the implementation of best practices as concerns (secondary) prevention of hamstring injuries to date, these muscle injuries present the tendency to occur more frequently as the time goes on. Because of the high reoccurrence risk, the ...
Genetic risk factors for Alzheimers's disease: a search for pathomechanisms. University of Antwerp
IMPLEMENTATION OF GENOME-WIDE CELL-FREE DNA SEQUENCING FOR THE EARLY IDENTIFICATION AND EFFICIENT MANAGEMENT OF HIGH-RISK PREGNANCIES KU Leuven
IMPLEMENTATION OF GENOME-WIDE CELL-FREE DNA SEQUENCING FOR THE EARLY IDENTIFICATION AND EFFICIENT MANAGEMENT OF HIGH-RISK PREGNANCIES
In prenatal diagnosis, NIPT (non-invasive prenatal testing) has been introduced as a safe and reliable screening test for common fetal chromosomal aneuploidies (trisomy 21, 18 and 13). The test is based on sequencing fetal cell-free DNA (cffDNA) in the maternal circulation of pregnant women. In 2013, ...
Analysis of user privacy in online location-based services KU Leuven
Location-based services (LBSs) have transformed social interactions and personal experiences in the digital landscape. The widespread adoption of smartphones, equipped with GPS sensors, has been instrumental in the rapid integration of LBSs into our daily lives. Notably, LBSs stand as among the most popular applications on major app stores, appreciated by users for their capacity to enhance social connectivity. These services enable users to ...