Peroxisomal membrane dynamics in mammalian cells. KU Leuven
The necessity of functional peroxisomes for normal human development is underscored by the existence of at least 17 hereditary diseases with the cerebro-hepato-renal syndrome of Zellweger, a disorder due to defective peroxisome formation, as prototype. In order to regulate peroxisome function and restrain damage during cellular aging, new peroxisomes need to be formed, and superfluous and non-functional peroxisomes have to be (selectively) ...