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Pathogénicité comparée des variétés de Cryptococcus neoformans Institute of Tropical Medicine
Characterization and pathogenicity of Pratylenchus vandenbergae stat. nov. (Tylenchina: Pratylenchidae), a highly pathogenic root-lesion nematode parasitizing crops in Kenya and South Africa Ghent University
A highly fecund root-lesion nematode parasitizing a variety of crops was discovered and found to be widespread in Kenya and South Africa. These populations were molecularly identical to Pratylenchus teres teres and P. teres vandenbergae based on D2-D3 of 28S rDNA and Hsp90 sequences. However, based on morphological differences with the original description of P. teres and its different geographical distribution, Pratylenchus vandenbergae stat. ...
A systematic review of progranulin concentrations in biofluids in over 7,000 people-assessing the pathogenicity of GRN mutations and other influencing factors. Flanders Institute for Biotechnology
Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML KU Leuven
Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development KU Leuven
Since May 2022, mpox virus (MPXV) has attracted considerable attention due to a multi-country outbreak. Marked differences in epidemiology, transmission, and pathology between the 2022 global mpox outbreak (clade IIb) and classical mpox disease, endemic in Africa (clades I and IIa) have been highlighted. MPXV genome analysis has identified the genomic changes characterizing clade IIb and the drivers of MPXV rapid evolution. Although mpox cases ...
Components of TOR and MAP kinase signaling control chemotropism and pathogenicity in the fungal pathogen Verticillium dahliae KU Leuven
Filamentous fungi can sense useful resources and hazards in their environment and direct growth of their hyphae accordingly. Chemotropism ensures access to nutrients, contact with other individuals (e.g., for mating), and interaction with hosts in the case of pathogens. Previous studies have revealed a complex chemotropic sensing landscape during host-pathogen interactions, but the underlying molecular machinery remains poorly characterized. ...
Toward reporting standards for the pathogenicity of variant combinations involved in multilocus/oligogenic diseases. Vrije Universiteit Brussel University of Antwerp Ghent University
Although standards and guidelines for the interpretation of variants identified in genes that cause Mendelian disorders have been developed, this is not the case for more complex genetic models including variant combinations in multiple genes. During a large curation process conducted on 318 research articles presenting oligogenic variant combinations, we encountered several recurring issues concerning their proper reporting and pathogenicity ...
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2 Ghent University
BackgroundThe distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) variant classification system.MethodsData for 10,373 ...
Compendium of clinical variant classification for 2,246 unique ABCA4 variants to clarify variant pathogenicity in Stargardt disease using a modified ACMG/AMP framework Ghent University
Biallelic variants in ABCA4 cause Stargardt disease (STGD1), the most frequent heritable macular disease. Determination of the pathogenicity of variants in ABCA4 proves to be difficult due to (1) the high number of benign and pathogenic variants in the gene; (2) the presence of many rare ABCA4 variants; (3) the presence of complex alleles for which phasing data are absent; (4) the extensive variable expressivity of this disease and (5) reduced ...