Modulators of the microtubule network in the pathogenesis of Amyotrophic Lateral Sclerosis KU Leuven
Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disorder with rapid progression resulting in a fatal outcome on average only afew years after onset of first symptoms. Patients suffering from ALS present with muscle weakness, atrophy and spasticity due to loss of upper and lower motor neurons located in the motor cortex, brain stem and spinal cord. In approximately 20% of familial ALS the disease is caused by mutations in the ...