Projects
Dengue virus infection of endothelial cells: Pathogenesis and antiviral potential of glycosaminoglycan targeting KU Leuven
Dengue viruses (DENV) are single-stranded positive-sense RNA viruses that belong to the family of the Flaviviridae, together with other important human pathogens (e.g. yellow fever virus and West Nile virus). Dengue is currently considered to be the most important arthropod-borne vial disease in humans. Four genetically distinct, but serologically related serotypes (DENV 1-4) are transmitted to humans by mosquitoes of the ...
The role of the adipose tissue in the pathogenesis of insulin resistance and increased disease susceptibility in high yielding dairy cows Ghent University
Obesity around the moment of calving increases the risk to develop metabolic, infectious and reproductive diseases in high yielding dairy cows. In this project, the role of the adipose tissue in the parthogenesis of these diseases, will be examined macroscopically, microscopically and molecularly.
Molecular pathogenesis in head and neck cancer: role tyrosine kinases. KU Leuven
In this work we primarily aimed to identify potential starting points for new therapeutic targeting ...
Can high-resolution optical projection tomography of the interplay between cryptococci and macrophages unravel the enigmas in pulmonary and cerebral cryptococosis pathogenesis? KU Leuven
Scientific state-of-the-art & aims of this proposal:
Cryptococcus neoformans and C. gattii are encapsulated yeasts that can cause life-threatening disease in both immune-competent and immune-suppressed individuals (e.g. cancer therapy patients or patients with AIDS). Cryptococcosis affects the lung and may spread to the brain, manifesting itself by meningitis or pseudocystic brain lesions. It ...
Mucus, the missing link in the pathogenesis of necrotic enteritis Ghent University
C. perfringens (CP) is the causative agent of many enteric diseases in both animals and humans, including necrotic enteritis (NE) in broilers, a disease characterized by necrosis and inflammation of the small intestine. In addition to NetB toxin, other virulence factors essential for NE disease development have been identified, although their function remains unknown. This project focusses on the early stages of NE pathogenesis with great ...
Vector-free transmission of Japanese encehalitis virus (JEV) in pigs - increased risk associated with a potential emergence: Study of JEV pathogenesis in pigs upon infection via different inoculation route Ghent University
The goals of this project are:
- to finalize the administrative procedures necessary to obtain the permission to work with Japanese encephalitis virus (JEV) at CODA-CERVA.
- to perform an experimental infection study whereby pigs will be infected with JEV via three inoculation routes (oronasal inoculation to mimic the vector-free transmission and intradermal inoculation of virus alone or of virus combined with mosquito ...
The role of the innate immune system in the pathogenesis of systemic juvenile idiopathic arthritis: advances in understanding KU Leuven
Systemic juvenile idiopathic arthritis (sJIA) is a severe autoinflammatory childhood-onset immune disorder, classified as one of the JIA subtypes. Patients clinically present with fever, skin rash, enlarged lymph nodes (LNs), spleen and/or liver, and develop arthritis. Haematologically, neutrophilia (including immature neutrophils), leukocytosis, anaemia, and thrombocytosis is noticed. Patients have high plasma cytokine levels of ...
The molecular pathogenesis of Fuchs' endothelial corneal dystrophy. KU Leuven
In this doctoral thesis, we have investigated the pathogenesis of late-onset Fuchs’ endothelial corneal dystrophy (FECD).
FECD is a degenerative disorder of the corneal endothelium (CE). The CE is the inner layer of the cornea (the cornea is the transparent front part of the eye). The cornea does not contain blood vessels, but receives water and nutrients from the anterior eye chamber fluid (a.k.a. aqueous humor) and the tear ...