Projects
Accelerating the Functional Maturation of Human Fast-Spiking Inhibitory Neurons KU Leuven
Inhibitory cortical interneurons are thought to underlie several neurological disorders, such as autism, schizophrenia, and epilepsy. In particular, the loss or defects of fast-spiking inhibitory interneuron is often observed. Due to this, many studies have used transplantation of interneuron progenitors or human stem cell derived inhibitory interneurons as candidates for cell based therapies. However, the current protocol to make functional ...
Optogenetic interrogation of the role of interneuron subtypes in age-dependent visual cortex plasticity in mice KU Leuven
The intrinsic capacity of the mammalian brain to recover from lesions early in life gradually loses strength and impact on brain function with age. Ocular dominance plasticity is one of the best studied examples of experience- and age-dependent modifications of visual cortical circuitry. Several interventions like dark exposure and GABAA receptor antagonist treatment have revealed how inhibitory synaptic transmission imposes limitations on ...