In vivo study of the functional role of brain adenosine 2A and glutamate mGLuR5 receptors in movement disorders KU Leuven
Parkinson’s disease (PD) and Huntington’s disease (HD) are movement disorders, without effective therapy. Dopamine deficiencies play a major role in these disorders, but also the brain adenosine and glutamate systems are dysregulated. Ex vivo studies point towards a role of the adenosine 2A receptor (A2A-R) in the pathogenesis of PD and HD, especially on the motor and cognitive domains. The metabotropic glutamate receptor type 5 (mGLuR5) ...