Karlsruhe Institute of Technology (KIT), University of Florence, Careggi University Hospital, University Medical Center Göttingen (UMG),
Medicinal Chemistry (UAMC)PaCaNano hypothesizes that therapeutic failure in pancreatic cancer (PC) can be overcome via a novel nanoparticle (NP) technology that allows targeting both cancer and stroma cells. To deliver proof-of-concept, we have selected gemcitabine phosphate (GemP) nanoparticles, recently developed by project partners KIT and UMG. These NPs have a very high gemcitabine load (80% by mass) and have already shown preclinical promise in PC. PaCaNano aims to ...