Publications

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Characterization of Mycobacterium tuberculosis var. africanum isolated from a patient with pulmonary tuberculosis in Brazil Institute of Tropical Medicine

Marcelo Fouad Rabahi, Emilyn Costa Conceicao, Luisa Oliveira de Paiva, Marcos Vinicius Muniz Lemes Souto, Maria Carolina Sisco, Jacobus de Waard, Paulo Cesar de Souza Caldas, Fatima Fandinho, Jesus Pais Ramos, Luciana Distasio de Carvalho, et al.

Human tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC), including Mycobacterium tuberculosis var. tuberculosis (MTB) and Mycobacterium tuberculosis var. africanum (MAF). While MTB is isolated worldwide, MAF is almost completely restricted to the African continent, and despite the historical proximity between Brazil and Africa during the slave trade, no case of TB being caused by MAF has been reported in ...

Effect of applying a treatment threshold in a population. An example of pulmonary tuberculosis in Rwanda Institute of Tropical Medicine University of Antwerp

Jozef Van den Ende, J Mugabekazi, Juan Martin Moreira, E Seryange, P Basinga, Z Bisoffi, Joris Menten, M Boelaert
Purpose Clinicians often think treatment thresholds should be adapted to the setting. We intended to explore the effect in terms of harm because of false negatives and true and false positives of the application of a treatment threshold for pulmonary tuberculosis from a patient's perspective at different prevalence levels in a developing country. Methods In a cohort of 300 patients with chronic cough, we estimated the prevalence of pulmonary ...

Assessment of an ELISA for serodiagnosis of active pulmonary tuberculosis in a Cuban population KU Leuven

Julio Cesar Ayala, Elsa Pimienta, Caridad Rodriguez, Monica Sarzo, Jony Jones, Carlos Vallin, Alina Guerrero, Maria Teresa Milanés, Jozef Anné, Godelieve Vanmellaert, et al.
© 2015 Asian Pacific Tropical Medicine Press. Objective: To explore the serodiagnostic potential of the five recombinant Mycobacterium tuberculosis antigens CFP-10 (Rv3874), ESAT-6 (Rv3875), APA (Rv1860), PstS-1 (Rv0934), Ag85A (Rv3804c) and their combination in a Cuban population with active pulmonary tuberculosis. Methods: The serodiagnostic potential of the recombinant antigens rESAT-6, rCFP-10, rAPA, rPstS-1 produced in Escherichia coli, ...

Household Air Pollution Is Associated with Chronic Cough but Not Hemoptysis after Completion of Pulmonary Tuberculosis Treatment in Adults, Rural Eastern Democratic Republic of Congo Hasselt University KU Leuven

Patrick D. M. C. Katoto, Aime Murhula, Tony Kayembe-Kitenge, Herve Lawin, Bertin C. Bisimwa, Jean Paul Cirhambiza, Eric Musafiri, Freddy Birembano, Zacharie Kashongwe, Bruce Kirenga, et al.
Little is known about the respiratory health damage related to household air pollution (HAP) in survivors of pulmonary tuberculosis (PTB). In a population-based cross-sectional study, we determined the prevalence and associated predictors of chronic cough and hemoptysis in 441 randomly selected PTB survivors living in 13 remote health zones with high TB burden in the South Kivu province of the Democratic Republic of Congo (DRC). Trained ...

Nontuberculous mycobacteria among pulmonary tuberculosis patients: a retrospective Belgian multicenter study KU Leuven

S De Keukeleire, V Mathys, S Van den Wijngaert, M Van De Vyvere, S Jonckheere, H De Beenhouwer, A De Bel, W Arrazola de Onate, M Wanlin, D Piérard, et al.
OBJECTIVES: Currently, there are no European data about the frequency and clinical significance of nontuberculous mycobacteria (NTM) grown from respiratory samples during the treatment of tuberculosis (TB). We determined the frequency and clinical significance of NTM isolated before or during pulmonary tuberculosis treatment in Belgian laboratories. METHODS: We conducted a nationwide retrospective multicenter cohort study on the co-isolation of ...

Evaluation of clinical prediction rules for respiratory isolation of inpatients with suspected pulmonary tuberculosis Institute of Tropical Medicine

Lely del Rosario Solari Zerpa, C Acuna-Villaorduna, A Soto, Patrick Van der Stuyft
Background. In the framework of hospital infection control, various clinical prediction rules (CPRs) for respiratory isolation of patients with suspected pulmonary tuberculosis (PTB) have been developed. Our aim was to evaluate their performance in an emergency department setting with a high prevalence of PTB. Methods. We searched the MEDLINE and OVID databases to identify CPRs to predict PTB. We used a previously collected database containing ...

Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community Hasselt University

Patrick Katoto, Tony Kayembe-Kitenge, Krystal Pollitt, Dries MARTENS, Manosij Ghosh, Jean Nachega, Benoit Nemery, Tim NAWROT
Telomere length (TL) is a marker of ageing and mitochondrial DNA (mtDNA) is an early marker of inflammation caused by oxidative stress. We determined TL and mtDNA content among active pulmonary tuberculosis (PTB) patients to assess if these cellular biomarkers differed between artisanal miners and non-miners, and to assess if they were predictive of treatment outcome. We conducted a prospective cohort study from August 2018 to May 2019 involving ...

Algorithm for the diagnosis of smear-negative pulmonary tuberculosis in high-incidence resource-constrained settings Institute of Tropical Medicine

Alonso Ricardo SOTO TARAZONA, Lely del Rosario Solari Zerpa, J. Agapito, E. Gotuzzo, R. Accinelli, D. Vargas, V. Acurio, Francine Matthys, Patrick Van der Stuyft
OBJECTIVES: Diagnosis of smear-negative pulmonary tuberculosis (SNPT) remains a challenge, particularly in resource-constrained settings. We evaluated a diagnostic algorithm that combines affordable laboratory tools and a clinical prediction rule (CPR). METHODS: We derived, based on published evidence, a diagnostic algorithm for SNPT. Sputum concentration constitutes its first step. In suspects with negative results, SNPT probability is ...

Evaluation of the diagnostic utility of fiberoptic bronchoscopy for smear-negative pulmonary tuberculosis in routine clinical practice Ghent University

Alonso Ricardo Soto Tarazona, Daniela Salazar, Vilma Acurio, Patricia Segura, Patrick Van Der Stuyft
We evaluated the diagnostic yield of fiberoptic bronchoscopy for the diagnosis of smear-negative pulmonary tuberculosis in patients treated at a referral hospital in Lima, Peru. Of the 611 patients who underwent the procedure, 140 (23%) were diagnosed with tuberculosis based on the analysis of BAL samples. Being young and being male were significantly associated with positive cultures. In addition, 287 patients underwent post-bronchoscopic ...