Projects
Cellular co-factors of HIV: protein-protein interactions as novel drug targets Ghent University
Our objective is to increase basic understanding of protein-protein interactions, to develop technology to identify and validate protein-protein interaction relevent for human disease and to develop assays and evaluate inhibitors of protein-protein interaction. Specifically, we want to develop novel treatment strategies for HIV infection by targeting cellular co-factors involved in HIV replication: Lens Epithelium Derived Growth Factor ...
RiPPing through pathogenic bacteria and protein-protein interactions KU Leuven
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a rapidly expanding class of chemically and structurally diverse bacterial natural products. Many exhibit therapeutically important biological activities, such as antibiotic, antifungal, insecticidal, immunomodulating and anti-cancer activities. The relaxed substrate specificity of RIPP biosynthetic enzymes, together with the increasing availability of methods to ...
A fluorescence-based tool for protein-protein interactions analysis and identification of novel processes of fluconazole susceptibility in Candida species KU Leuven
Candida species at the same time represent the predominant commensal fungi in the human gut microbiome and are among top 6 most common causes of serious fungal infections worldwide. Our research imperatives are better understanding the biology of these opportunistic pathogens that drives their dual lifestyle as well as finding effective treatments for the eradication of Candida infections.
Mapping the complex ...
Molecular pathomechanisms of HSPB1 and HSPB8 mutations in motor neuropathies: study of protein-protein interactions and axonal transport in cellular and animal models. University of Antwerp
Financing IOF-program: ConFoBodies to uncover protein-protein interactions for drug discovery Vrije Universiteit Brussel
Molecular pathomechanisms of HSPB1 and HSPB8 mutations in motor neuropathies: study of protein-protein interactions and axonal transport in cellular and animal models. KU Leuven
‘VIROTRAP’: A new strategy for the detection of protein-protein interactions Ghent University
This project aims for the introduction, optimization and application of a new technology based on virus biology for the detection of protein interactions. In this VIROTRAP-technology, we couple a bait protein to the p55 Gag protein of HIV-1. This fusion protein forms ‘virus like particles’ which ‘trap’ endogenous interaction partners and can be harvested from the cell supernatant, after which we identify the interaction partners by e.g. mass ...
Analysis of Promyelocytic Leukemia Nuclear Bodies (PML-NBs) during virus infection: application of the TAP method and exploration of a new strategy fot detection of protein-protein interactions. University of Antwerp
Protein-protein interactions: from bench to bedside Ghent University
Protein-protein interactions (PPI's) are at the heart of cellular function. In our Methusalem consortium, we will apply several techniques including MAPPIT and protein crystallography in order to obtain a deeper insight into the role of PPI's at several levels: from large-scale interactome mapping and signalling pathways down to the molecular details of designated protein interaction pairs. This program incorporates the interaction between ...