Projects
Deposition of atmospheric pressure plasma-polymerized thiol-rich coatings on nanofibrous samples: unravelling the occurring plasma chemistry and exploring tissue engineering applications Ghent University
This project aims to develop thiolated nanofibers (NFs) using non-thermal plasma polymerization Surprisingly, to date, no knowledge on atmospheric pressure plasma deposition of thiol-rich coatings on NFs is available, while this technology offers several advantages, including dry processing and fiber morphology preservation To fully examine the potential of thiol plasma polymerization, 4 precursors (1-propanethiol, 1,3-propanedithiol, ...
High resolution 500 Mhz Nuclear Magnetic Resonance platform for the chemistry of single molecules, nanostructures, supramolecular objects and macromolecules. Ghent University
Establishing a 500 MHz NMR Platform to investigate the structure of, and the interactions between, molecules and materials from chemical synthesis. This can form the basis of new and innovative applications, ranging from more efficient nanomaterials to the development of new drugs.
The role of organic molecules and surface chemistry in biotic and abiotic calcium sulphate precipitation Vrije Universiteit Brussel
"DECORATE": moDulation of Tax1 - PDZ domain protEin – protein interaCtiOns foR the treAtment of HTLV-1 inducEd diseases Vrije Universiteit Brussel
(ATL). The design of targeted therapeutic agents against ATL, however, remains a considerable
challenge in medicine. Here, we propose a strategy aiming to identify and validate both small
molecule and peptidomimetic inhibitors of protein-protein interactions (iPPIs) between Tax1 – the
main viral oncoprotein – and human ...
Biomimetic furan oxidation: a "Trojan Horse" strategy for the formation of covalent protein / protein complexes. Ghent University
Development of lanthanide polyoxometalate complexes as regioslective reagents for protein cleavage. KU Leuven
Next generation sulfur(VI)-fluoride probes for activity-based protein profiling. KU Leuven
In this work, we will advance reactive molecules ('probes') for the study of proteins. The need for development of new probes stems from the fact that different types of probes bind diverse proteins. Once a protein is tagged, it can be analyzed and identified, and in cases where the enzyme appears to play a role in human diseases, a drug candidate can be developed based on the employed probe. The approach in this project is novel in the ...
G Protein peptidomimetics As generic keyS to alloStErically unlock the suPerfAmily of G pRoTeincOUpled recepTors [PASSEPARTOUT Vrije Universiteit Brussel
largest family of cell surface receptors and they participate in many aspects of human physiology,
which explains that around 40% of all drugs target these receptors. Yet, a majority still needs to be
therapeutically harnessed, justifying the development of tools to support ligand discovery. Here, we
aim to develop a generic ...
Design, synthesis and evaluation of protein kinase D inhibitors forcancer treatment KU Leuven
Cancer is gradually becoming the leading cause of premature death in our global society. In Europe, approximately one in three develops cancer before the age of 75. With a global death rate of almost 10 million individuals per year, there is a clear need for better treatments. This thesis aimed at developing novel and potent small molecule inhibitors of Protein Kinase D (PKD), an attractive anti-cancer drug target.
In first instance, ...