Investigation of the interaction between GzmB and novel potent inhibitors: structural and kinetic analysis. University of Antwerp
Granzyme B (GzmB) is a serine protease involved in the targeted destruction of tumor cells and is stored in granules of cytotoxic T (CD8+) and natural killer (NK) cells. After perforin-mediated delivery to the tumor cell cytoplasm, GzmB is responsible for initiating caspase-mediated apoptosis. As such, GzmB is a strong candidate for monitoring tumor cell-directed killing, which renders the cytotoxic activity of CD8+ and NK cells even promising ...