Characterization of the biological functions of progranulin in axonal regeneration and frontotemporal lobar degeneration/amyotrophiclateral sclerosis, a translational study. KU Leuven
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder characterized by progressive loss of synapses, axonal connections and neuronal cell bodies primarily affecting the frontal and anterior temporal lobes. After Alzheimer’s disease, it is the second most common form of dementia in patients under 65. The disease can present with behavioral or language disturbances and has devastating effects on patients and their families. ...