The PHF6 - TLX1 cooperativity and the IL7R-JAK3 signaling axis as drug target in PHF6 deficient T-ALL Ghent University
T -cell acute lymphoblastic leukemia (T -ALL) arises from uncontrolled proliferation and arrested differentiation of precursor T-cells. Since many factors contributing to the pathogenesis of T-ALL are still unknown, a comprehensive analysis of the molecular pathways involved in this disease will be crucial to fully understand the mechanisms of malignant T-cell transformation and to develop novel strategies for targeted and less toxic ...