Publications
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Analysis of new persistence determinants in Pseudomonas aeruginosa identified by high-throughput screening KU Leuven
Pseudomonas aeruginosa is een opportunistische pathogeen die ernstige in fecties veroorzaakt in immuungecompromitteerde personen. Vooral bij muco viscidose patiënten evolueren deze infecties naar een chronisch karakter en vormen zij de voornaamste oorzaak van het falen van de longfunctie. Naast de intrinsieke tolerantie tegen een breed spectrum van antibiotica , vormen de stijgende resistentie en de biofilmvorming van deze bacterie een toenemend ...
Environmental, mechanistic and evolutionary landscape of antibiotic persistence KU Leuven Flanders Institute for Biotechnology
Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and contributing to the spread of antibiotic resistance, thereby threatening the successful treatment of bacterial infections. One potential contributing factor in persistent infections is antibiotic persistence, which involves the survival of transiently tolerant subpopulations of bacteria. This review summarizes the current understanding of antibiotic ...
Bacterial Persistence - Methods and Protocols KU Leuven
This volume presents a collection of methods that have contributed to the current understanding of bacterial persisters. Chapters in the book detail general guidelines for measuring persister levels in bacterial cultures, strategies to enrich and resuscitate persister subpopulations, single-cell approaches for visualizing and characterizing persisters, omics techniques and cellular and animal models for studying persistence. Written in the ...
Hardiness differentiates military trainees on behavioural persistence and physical performance KU Leuven
Hardiness is a personality trait that drafts courage and motivation during adversity. Research showed that hardiness differentiates elite athletes from their lower rank competitors. In the domain of sport psychology, hardiness also strongly predicts physical performance. Because the military occupation requires resilience and excellence in physical performance, researchers investigated hardiness and behavioural persistence during training. ...
Effects of responsibility and mood on painful task persistence KU Leuven
BACKGROUND AND OBJECTIVES: Not just avoidance behaviour, but also painful task persistence might be a risk factor for development and maintenance of pain complaints. In seeking to understand these dysfunctional patterns of task performance, it has been suggested that mood influences the individuals' motivation to persist in a task depending on the interpretation of current mood within a certain motivational context. The aim of the present study ...
Persistence of Late Substantial Patient-Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study KU Leuven
PURPOSE: This report describes the persistence of late substantial treatment-related patient-reported symptoms (LAPERS) in the multi-institutional EMBRACE study on magnetic resonance image guided adaptive brachytherapy in locally advanced cervical cancer (LACC). METHODS AND MATERIALS: Patient-reported symptoms (European Organization for Research and Treatment of Cancer [EORTC]-C30/CX24) and physician-assessed morbidity (Common Terminology ...
First-onset and persistence of suicidal ideation in university students: A one-year follow-up study KU Leuven
BACKGROUND: Longitudinal evidence about risk and protective factors for suicidal ideation among university students is limited. METHODS: 12-month first-onset and persistence of suicidal ideation (SI) among Spanish first-year university students were estimated using baseline (T1) and 12-month follow-up (T2) online surveys. Information about STBs, childhood/adolescence adversities, positive relationships, mental disorders, recent stressful ...
The persistence of carbon in the African forest understory KU Leuven Ghent University
Quantifying carbon dynamics in forests is critical for understanding their role in long-term climate regulation1-4. Yet little is known about tree longevity in tropical forests3,5-8, a factor that is vital for estimating carbon persistence3,4. Here we calculate mean carbon age (the period that carbon is fixed in trees7) in different strata of African tropical forests using (1) growth-ring records with a unique timestamp accurately demarcating 66 ...