Projects
Development of polymeric nanoparticle carriers for targeted drug delivery to oocytes. University of Antwerp
The many faces of ATP13A2 in regulating the pathophysiology of alpha-synuclein KU Leuven
PD is the most common neurodegenerative movement disorder that leads to many motor symptoms such as resting tremor, rigidity, slowness of movement, and postural instability. The incidence of the disease is estimated to double with increased life expectancy in 20 years. One of the hallmarks of PD is the presence of LB in the remaining neurons, which mainly consist of the protein α-synuclein (αsyn).
Genetic mutations or multiplications of ...
The role of the paraoxonase gene family in obesity and obesity-associated liver disease following exposure to environmental pollutants or medical intervention strategies. University of Antwerp
Physiological characterization of tolerance of sunflower Clearfield hybrids to herbicide imazamox Hasselt University
Precision genomics in neurodegenerative brain disease: from patients to small model organisms and single cells Ghent University
We will study genomic aspects of rare neurodegenerative brain disorders (NBD). First, we will establish a multidisciplinary clinical neurogenetics program at UZ Gent. Second, we will use fruit flies to study the potential pathogenic nature of novel NBD-related genetic variants. Third, we will use single-cell sequencing to study the role of genomic mosaicism in neurodegeneration.