Projects
Heme oxygenase-1 and chronic kidney disease: A translational study of oxidative stress and atherogenesis KU Leuven
In advanced kidney disease the prevalence of atherosclerotic cardiovascular disease is high and nearly equivalent across age groups. Recent data indicate that even minor renal dysfunction impacts on the onset of cardiovascular disease (CVD). Many authors hypothesize that increased oxidative stress is the unifying concept that initiates and feeds this problem. Several findings in uremic patients point towards an imbalance favoring the ...
The oxidative stability of n-3 LC-PUFA in meat batter model systems enriched with microalgae KU Leuven
The health benefits of omega-3 long chain poly-unsaturated fatty acids (n-3 LC-PUFA) are generally recognized. Unfortunately, in most Western countries, the recommended daily intake of these compounds is rarely met. Therefore, enrichment of commonly occurring foods can boost intake of these fatty acids. Meat products are an interesting target, as they contain high-quality proteins and are a source of iron. Meat products could be enriched with ...
Taking control of oxidative stress in the male germline: lipid-focused strategies to prevent infertility Ghent University
Infertility is a critical worldwide health burden, with 1 in 6 couples currently seeking the help of assisted reproductive technology and at least 50% of infertile cases involving a male factor. This is concerning as there is now compelling evidence that poor sperm quality may be prescient of major systemic diseases such as cardiovascular disease and diabetes. Although many male infertility cases are diagnosed as idiopathic, up to 80% of ...
Development of nanoporous oxides to eliminate oxidative stress in the human gastrointestinal tract. KU Leuven
Mechanisms underlying increased tolerance of oxidative phosphorylation by fetal liver compared with bone marrow derived hematopoietic stem cells KU Leuven
Additional insights in signals underlying symmetrical self-renewing cell divisions typical for fetal liver (FL) hematopoietic stem cells (HSCs), but not bone marrow (BM) HSCs would be instrumental for designing methods that allow true adult HSC expansion without inducing differentiation or ageing. We recently described that unlike adult HSCs, FL HSCs use oxidative phosphorylation (OxPhos), which might allow their greater expansion. However, ...
Towards improved high capacity layered electrode materials for Liion batteries through atomic-level understanding of the redox reactions. University of Antwerp
DeLock - DEnitrification unLOCKed. Unlocking the N2O-reduction capacity of denitrifying microbial communities to combat N2O emissions during wastewater treatment processes. Ghent University
In the era of global warming, solutions to reduce greenhouse gases emissions are urgently needed. Nitrous oxide (N2O) has a global warming potential almost 300 times the one of CO2, and accounts for 8% of total anthropogenic GHG emissions. The majority
Assessing the biological capacity for marine ecosystem resilience: Acclimation and adaptation in a rapidly changing environment Ghent University
Global change alters marine ecosystems and the services they provide. Whether these services are at risk depends on the resilience of organisms, populations and communities. We use a tight interplay of laboratory experiments and simulation modeling to unravel the potential of marine organisms and communities to acclimate, adapt and/or disperse, and to retain ecological functioning under realistic future ocean scenarios.
Assessing the biological capacity for marine ecosystem resilience: Acclimation and adaptation in a rapidly changing environment Ghent University
Global change alters marine ecosystems and the services they provide. Whether these services are at risk depends on the resilience of organisms, populations and communities. We use a tight interplay of laboratory experiments and simulation modeling to unravel the potential of marine organisms and communities to acclimate, adapt and/or disperse, and to retain ecological functioning under realistic future ocean scenarios.