Predicting outcome after total knee replacement surgery in patients with knee osteoarthritis: a prospective study on the role of altered central pain processing in addition to structural and functional impairments related to knee osteoarthritis. University of Antwerp
The role of the RANKL/RANK/OPG pathway in the cross talk between synovial fibroblasts and synovial myeloid cells in erosive hand osteoarthritis. Ghent University
Erosive hand osteoarthritis is a unique subset of osteoarthritis. Current knowledge on its pathogenesis is limited. Our clinic has mastered a new technique, making it possible to retrieve synovial tissue from finger joints for molecular analysis. This project aims to unravel the
role of RANKL and the crosstalk between synovial fibroblasts and myeloid cells in erosive hand osteoarthritis.
Rehab-4-earlyOA: Mechanobiology-driven rehabilitation of early osteoarthritis through optimized multi-scale biomechanics KU Leuven
Clinical phenotypes in persons with hip osteoarthritis and prognostic factors of outcome following total hip arthroplasty Hasselt University
Monitoring knee loading in patients with knee osteoarthritis using real-world data - Insights gained from biomechanical modelling approach based on wearable sensor data KU Leuven
Osteoarthritis (OA) is the most common joint disease, that progressively undermines cartilage function. Knee OA Patients suffer from pain and impaired locomotor function. Patients minimize pain and optimize gait function through self-learned compensations. One of the first conservative treatment strategies in knee OA is intermittent pain medication, aiming to improve gait function by alleviating pain. To date no known cure or proven strategy ...
Osteoarthritis is the most common joint disorder worldwide, for which no cure exists. Increasing evidence suggests that the Wnt pathway plays a critical role in this disease and may be an effective target for therapy. However, modulation of this cascade to safeguard cartilage health remains a challenge, as we fail to fully understand how it is regulated. My research program aims to dissect molecular mechanisms that control the Wnt pathway in ...
Effect of Human Dental Pulp Stem Cells on the Regeneration of Articular Cartilage: a Study in an Ovine Model of Osteoarthritis. Hasselt University
Osteoarthritis (OA) is the most common form of arthritis and one of the most prevalent chronic joint disease that especially affects the knee joint. Roughly, knee OA affects 12% of people aged 60 years or older. Although a well-documented joint disorder, the cause of OA is not fully understood, and despite medical advances, there is no effective treatment for OA. Excessive knee loading and/or changes in the normal load bearing contact can ...