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An approach to correlate the CTDIvol to organ dose for thorax and abdomen CT taking tube current modulation and patient size into account KU Leuven
Purpose: To estimate conversion factors for calculating effective dose (E) and organ dose taking tube current modulation (TCM) and patient size into account in adult thorax and abdomen CT examinations. Method: 99 consecutive adult patients were included in this study. All examinations were performed with TCM (CareDose 4D, Siemens Definition Flash) at 120 kVp and 110 (thorax) and 200 (abdomen) reference mAs. E and organ dose were estimated with ...
What determines organ size differences between species? A meta-analysis of the cellular basis University of Antwerp
Little is known about how the characteristic differences in organ size between species are regulated. At the cellular level, the size of an organ is strictly regulated by cell division and expansion during its development. We performed a meta-analysis of the growth parameters of roots, and Graminae and eudicotyledonous leaves, to address the question of how quantitative variation in these two processes contributes to size differences across a ...
A dynamic ubiquitination balance of cell proliferation and endoreduplication regulators determines plant organ size Ghent University
Ubiquitination plays a crucial role throughout plant growth and development. The E3 ligase DA2 has been reported to activate the peptidase DA1 by ubiquitination, hereby limiting cell proliferation. However, the molecular mechanisms that regulate DA2 remain elusive. Here, we demonstrate that DA2 has a very high turnover and auto-ubiquitinates with K48-linkage polyubiquitin chains, which is counteracted by two deubiquitinating enzymes, ...
A dynamic ubiquitination balance of cell proliferation and endoreduplication regulators determines plant organ size. Flanders Institute for Biotechnology Ghent University
STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana Flanders Institute for Biotechnology Ghent University
The hippo tumor suppressor network: from organ size control to stem cells and cancer KU Leuven
The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation and maintain tissue homeostasis during development. We found that activation of Yorkie (Yki), the effector of the Hippo signaling pathway, causes separable effects on growth and differentiation of the Drosophila eye.We present evidence supporting a role for Yki in suppressing eye fate by downregulation of the core retinal determination genes. Other ...