Study Of Cooperating Oncogenes In The Development Of T-Cell Acute Lymphoblastic Leukemia Using CRISPR/Cas-Generated Cell And Mouse Models. KU Leuven
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease, which arises from the malignant transformation of developing T-cell progenitors. Survival rates are nowadays up to 90% in children and 40% in adults. However, current therapy is associated with many short-term and long-term side effects, and survival rates after relapse or primary resistance remain very low. To address this challenge, current research is ...