Projects
The metabolic syndrome, oxidative stress, and atherosclerosis. KU Leuven
Metals, oxidative stress and carotenoid-dependent colouration: does metal pollution fade the colour of great tits (Parus major)? University of Antwerp
Ecological and evolutionary implications of oxidative stress in aquatic invertebrates: UV radiation as a model pro-oxidant. KU Leuven
All organisms face stress imposed by the production of damaging reactive oxygen species during metabolism, so-called endogenous oxidative stress (OS). Due to human activities, organisms are also increasingly facing OS imposed by external factors such as UV radiation and pollutants. Populations exposed to UV radiation evolve defence mechanisms to cope with OS. Recent insights indicate that OS affects the evolution of life history traits, such ...
Modulation of the cGMP pathway by oxidative stress in smooth muscle relaxation and inflammation Ghent University
Using mouse transgenic technology it will be aimed to explain a number of observations questionning the existing paradigm about the activity of NO and sGC, and this in shock, the cardiovascular and the gastro-intestinal system.
The role of oxidative stress tolerance in the antibiotic resistance of biofilms formed by Gram-negative bacteria Ghent University
Our hypothesis is that cells in Gram-negative bacterial biofilms are more resistant to antimicrobial agents than planktonic cells because they are also better in coping with, and/or avoiding exposure to, oxidative stress than planktonic cells. We believe that strategies to deal with this oxidative stress are essential for the survival of treated biofilm cells. Using state-of-the-art molecular tools we will dissect the response of selected ...
The role of autophagy in the prevention of oxidative stress and cardiovascular disease by olive polyphenols. University of Antwerp
Developing a novel combination of immunotherapy with induction of oxidative stress to treat solid tumors. University of Antwerp
Post-translational modifications during the oxidative stress response in plants. Ghent University
This project will monitor selected post-translational modification events that are triggered by increased photorespiratory H2O2 levels in plants by using COFRADIC technology. Identified events will be subjected to a detailed functional analysis, including the generation of gain- and loss-of-function mutants and a detailed phenotyping effort in order to elucidate the functionality of the identified proteins.