Projects

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Oxidative stress as a constraint and cost of reproduction. University of Antwerp

Marcel Eens
Behavioural Ecology & Ecophysiology
In this project, I propose to address the following hypotheses using the canary (Serinus canaria) and the great tit (Parus major) as model species: prereproductive oxidative stress reduces subsequent reproductive investment; high parental effort in chick-rearing increases parental oxidative stress and reduces survival or future investment in reproduction; oxidative stress experienced during incubation reduces subsequent investment in ...

Targeting oxidative stress and metabolic dysfunctionin amyotrophic lateral sclerosis. KU Leuven

Ludo Van Den Bosch
Laboratory for Neurobiology (VIB-KU Leuven Center for Brain & Disease Research)

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and

fatal neurodegenerative disorder leading to the death of the patient

within three to five years after diagnosis. Oxidative stress and

dysregulated metabolism are both extensively linked to ALS. Given

the lack of efficient treatment possibilities for ALS, this project aims to

elucidate the therapeutic potential of modulating oxidative stress ...

The role of microRNAs in the regulation of inflammation and oxidative stress in monocytes during obesity and associated metabolic disorders. KU Leuven

Paul Holvoet
Department of Cardiovascular Sciences, Faculty of Economics and Business (FEB), Campus Brussels, Cardiology
Obesity is a chronic and complex disorder that is a major contributor to the global burden of disease and morbidity. It leads to the development of hyperglycemia and diabetes, dyslipidemia and hypertension (all components of the metabolic syndrome) and cardiovascular diseases. Blood monocytes and tissue macrophages are culprit cells in the increased inflammatory and oxidative stress state associated with obesity and the onset of obesity-induced ...

(De)coupling across life-history stages: oxidative stress and carry-over effects across metamorphosis. KU Leuven

Robby Stoks
Ecology, Evolution and Biodiversity Conservation

Most animals, including damselflies, have a life cycle with a larval stage separated from the adult stage by metamorphosis. There is evidence that these two life stages are not independent, indicating that the larval environment may influence adult traits. In this project I will investigate the (de)coupling of traits across metamorphosis with a focus on the mechanistic underpinnings. Firstly, I will study the negative coupling between larval ...

Investigation of immune and oxidative stress aberrancies in ADHD and the potential of polyphenol-rich plant extract supplementation in ADHD therapy. University of Antwerp

Nina Hermans
Natural Products and Food - Research and Analysis (NatuRA)
The general aim of this project is to improve understanding of immune and oxidative stress aberrancies in ADHD and to evaluate the effects of supplementation with Pinus pinaster bark extract on behaviour and comorbid symptoms and on immune, oxidative stress and antioxidant biomarkers, as compared to placebo, no intervention and MPH treatment.

Investigation of immune and oxidative stress aberrancies in ADHD and the potential of polyphenol-rich plant extract supplementation in ADHD therapy. University of Antwerp

Nina Hermans
Translational Neurosciences (TNW), Natural Products and Food - Research and Analysis (NatuRA)
The general aim of this project is to improve understanding of immune and oxidative stress aberrancies in ADHD and to evaluate the effects of supplementation with Pinus pinaster bark extract on behaviour and comorbid symptoms and on immune, oxidative stress and antioxidant biomarkers, as compared to placebo, no intervention and MPH treatment.

The involvement of neuroinflammation and oxidative stress on alpha-synuclein aggregation and intercellular pathology spread in Parkinson's disease. Vrije Universiteit Brussel

Ann Massie
Pharmaceutical Biotechnology and Molecular Biology
This project aims to validate neuroprotective compounds that are capable of preventing a-syn aggregation in vivo, by interference of inflammation and the NADPH oxidase related oxidative stress. Furthermore, we will investigate whether these mechanisms are involved in the spread of a-syn pathology. Two questions will be examined:
1) What is the relationship between oxidative stress, inflammation, and a-syn aggregation?
2) Can modulation ...

Metals, oxidative stress and carotenoid-dependent coloration: does metal pollution fade the colour of great tits (Parus major)? University of Antwerp

Marcel Eens
Behavioural Ecology & Ecophysiology
The main focus of this project is to asses the signal value of carotenoid colouration in relation to oxidative stress levels and diet quality in the great tit (Parus major). The great tit has a carotenoid based signal, namely the yellow breast colour. The brightness of this colour is linked to the condition and the quality of the bearer. The research will be conducted in a well known metal pollution gradient. We expect that birds in polluted ...

Metals, oxidative stress and carotenoid-dependent coloration: does metal pollution fade the colour of great tits (Parus major)? University of Antwerp

Marcel Eens
Behavioural Ecology & Ecophysiology
The main focus of this project is to asses the signal value of carotenoid colouration in relation to oxidative stress levels and diet quality in the great tit (Parus major). The great tit has a carotenoid based signal, namely the yellow breast colour. The brightness of this colour is linked to the condition and the quality of the bearer. The research will be conducted in a well known metal pollution gradient. We expect that birds in polluted ...

The role of oxidative stress in infection dynamics and treatment of leishmaniasis. University of Antwerp

Louis Maes
Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
The specific objectives of this research proposal are:¿ Optimisation and validation of EPR analysis for ex vivo quantification and identification of free radicals in macrophages.¿ Determining the role of oxidative stress in the survival of the Leishmania parasite in the macrophage.¿ Studying the link between oxidative stress and the action of current (antimonials) and new (PX-6518) antileishmanial compounds.