In arid regions fast growing broilers are often vulnerable to heat stress. There are indications that this is related to oxidative stress and that the dietary supply with antioxidatns may offer protection to heat stress. This is probably mediated by heat shock proteins. This project aims at getting more insight in these phenomena.
Cellular reactive oxygen species (ROS) at low and moderate
concentration can function as second messenger that integrate in the
intra- and intercellular signaling cascades to enable plant acclimation
to abiotic and biotic stresses. Exploiting the key regulators and
targets underlying oxidative stress signaling networks is therefore in
a high priority. It still remains fragmented for comprehensively
identifying ...
Cardiovascular disease (CVD) constitutes a major and increasing health burden in developed countries. The prediction is that the prevalence of these conditions will increase by ~60% over the next 20 years. Therefore, the development of novel treatments for patients with CVD becomes more and more urgent. Oxidative stress is an important molecular contributor to the pathogenesis of CVD. However, oxidative stress-related therapeutic strategies ...
In advanced kidney disease the prevalence of atherosclerotic cardiovascular disease is high and nearly equivalent across age groups. Recent data indicate that even minor renal dysfunction impacts on the onset of cardiovascular disease (CVD). Many authors hypothesize that increased oxidative stress is the unifying concept that initiates and feeds this problem. Several findings in uremic patients point towards an imbalance favoring the ...
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and
fatal neurodegenerative disorder leading to the death of the patient
within three to five years after diagnosis. Oxidative stress and
dysregulated metabolism are both extensively linked to ALS. Given
the lack of efficient treatment possibilities for ALS, this project aims to
elucidate the therapeutic potential of modulating oxidative stress ...
Most animals, including damselflies, have a life cycle with a larval stage separated from the adult stage by metamorphosis. There is evidence that these two life stages are not independent, indicating that the larval environment may influence adult traits. In this project I will investigate the (de)coupling of traits across metamorphosis with a focus on the mechanistic underpinnings. Firstly, I will study the negative coupling between larval ...