The role of the ORMDL3 susceptibility gene in the pathogenesis of asthma Ghent University
Asthma is a very common disease with up to 8% of children and 3% of adults in Belgium affected. Several studies have been performed to find out if the genetic makeup of an individual confers risk to develop the disease. A particular genetic locus on chromosome 17 (17q21) has been found in almost all genome wide association studies of asthma. This locus contains two genes (ORMDL3 and Gasdermin B) of which the expression is increased in ...