Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic Selection KU Leuven
The chemical diversification and enzymatic proliferation of artificial genetic polymers (xeno nucleic acids, XNAs) is an intriguing avenue of research, especially in view of potential applications in synthetic biology. One of the main goals in this area is to achieve the genetic reprogramming of novel microorganisms through the development of both chemical and biological tools. For this purpose, oligonucleotide analogues, showing good ...